Risk Factors for Keratoconus
Risk Factors for Keratoconus


Keratoconus is a progressive eye disorder characterized by the thinning and conical shape deformation of the cornea, the transparent front part of the eye. This condition leads to distorted vision, increased sensitivity to light, and astigmatism. Keratoconus usually manifests during the teenage years or early twenties and progresses over time, impacting visual acuity. While the exact cause is not fully understood, genetic factors and environmental influences may contribute to its development. Treatment options range from corrective lenses and contact lenses to surgical interventions like corneal collagen cross-linking or, in severe cases, corneal transplant. Early diagnosis and management are crucial in minimizing the impact of keratoconus on vision.

Keratoconus is a progressive eye condition that affects the cornea, leading to a cone-shaped deformation and causing visual impairment. This guide aims to provide valuable insights into the diagnosis and management of keratoconus, offering a comprehensive overview for those seeking information on this condition.

Keratoconus can cause blurry, distorted vision and sensitivity to light and glare. It can also affect your quality of life, making it difficult to work, read, watch TV, and drive.


Here are a few factors that may lead to this eye condition:


1. Genetic Predisposition:

Research suggests that genetics plays a significant role in the development of keratoconus. Individuals with a family history of the condition are at a higher risk of developing it themselves. Various genetic factors may influence the structure and stability of the cornea, making certain individuals more susceptible to keratoconus.


2. Collagen Imbalance:

The cornea is primarily composed of collagen, a structural protein that provides strength and elasticity to the tissue. In keratoconus, there appears to be an imbalance in the enzymatic processes responsible for maintaining the integrity of collagen fibers. This imbalance weakens the cornea, making it more prone to deformation.


3. Environmental Factors:

Certain environmental factors may contribute to the progression of keratoconus. Chronic eye rubbing, particularly in individuals with allergic conditions, has been linked to an increased risk of developing keratoconus. The mechanical stress caused by rubbing the eyes may contribute to the thinning and bulging of the cornea over time.


4. Hormonal Changes:

Hormonal changes, particularly during puberty, pregnancy, and menopause, have been suggested as potential triggers for the onset or progression of keratoconus. The exact mechanisms linking hormonal fluctuations to keratoconus are still being investigated, but hormonal changes may influence the structural stability of the cornea.


5. Connective Tissue Disorders:

Keratoconus has been associated with certain connective tissue disorders, such as Ehlers-Danlos syndrome and Marfan syndrome. These conditions affect the body's connective tissues, including collagen, and may contribute to the weakening of the cornea in individuals with keratoconus.


6. Oxidative Stress:

Oxidative stress, caused by an imbalance between the production of reactive oxygen species (ROS) and the body's ability to neutralize them, has been proposed as a potential factor in the development of keratoconus. Increased oxidative stress may lead to corneal damage and thinning.



Keratoconus is relatively common, affecting between 50 to 200 in 100,000 people. For most people, day-to-day life shouldn't be affected. Prescription glasses or contact lenses can correct your sight, and other treatment options can help even with advanced keratoconus.

Take the first step towards clearer vision – consult with experts at Rohit Eye Hospital today. Your vision matters, and with the right care, a brighter, clearer future is within reach.




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